Studying the pharmacokinetics of biotechnological medicinal products on the example of monoclonal antibodies

Therapeutic monoclonal antibodies (mAbs), which are developed to treat many pathologies, including cancer, autoimmune and infectious diseases, one of the fastest growing classes medicinal products. Given large number mAbs in pipeline continued interest from pharmaceutical companies, mAb market is expected continue grow coming years. To maximise both therapeutic benefit safety products this class, it essential that their pharmacological properties be carefully characterised understood. The aim study was analyse literature data on approaches studying pharmacokinetics mAbs. This review presents main physicochemical compares them with small molecules. article describes influence various factors pharmacokinetics. For example, such include method administration, hydrophilicity, charge mAb, individual characteristics patient (body weight, plasma albumin levels, genetic characteristics, etc.), concurrent administration other authors evaluated role intra- inter-individual variability pharmacokinetic parameters. rapid development group emergence new promising molecules indicative need pharmacodynamics detail class.